After losing his wife seven years earlier, the eccentric John Dolittle (Downey), famed doctor and veterinarian of Victorian England, hermits himself away behind the high walls of Dolittle Manor with only his menagerie of animals for company. But when Queen Victoria (Jessie Buckley) falls gravely ill, a reluctant Dolittle is forced to set sail on an epic adventure to a mythical island in search of a cure, regaining his wit and courage as he crosses old adversaries and encounters wondrous creatures.
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