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Moving around in LA (Los Angeles)

Hello everyone!

I am travelling to San Diego (plane) and I then want to get to LA.
What is the best way to do this (train/shuttle? can u give me the website, plz?

Also, I will be visiting Doheny eye institute and going to LAX the next day.

Which mid range hotels would you reccomend (I am a PhD student, so money is an issue =)

Thankssss =D